Scientists at KAIST have found a way to turn a tumor’s own immune cells into powerful cancer fighters—right inside the body. Tumors are packed with macrophages, immune cells that should attack cancer but are usually silenced by the tumor environment. By injecting a specially designed drug directly into tumors, researchers were able to “reprogram” these dormant cells to recognize and destroy cancer.
Cancer immunotherapy has been a game-changer, but many tumors still find ways to slip past the immune system. New research reveals a hidden trick: cancer cells can package the immune-blocking protein PD-L1 into tiny particles that circulate through the body and weaken immunotherapy’s impact. Scientists in Japan discovered that a little-known protein, UBL3, controls this process—and surprisingly, common cholesterol-lowering drugs called statins can shut it down.
A massive international study of more than 3,100 long COVID patients uncovered a striking divide in how brain-related symptoms are reported around the world. In the U.S., the vast majority of non-hospitalized patients described brain fog, depression, and anxiety, while far fewer patients in countries like India and Nigeria reported the same issues. The difference doesn’t appear to be about the virus itself, but about culture, stigma, and access to mental health care.
Researchers have discovered a biological switch that explains why movement keeps bones strong. The protein senses physical activity and pushes bone marrow stem cells to build bone instead of storing fat, slowing age-related bone loss. By targeting this “exercise sensor,” scientists believe they could create drugs that mimic exercise at the molecular level. The approach could protect fragile bones in people who are unable to stay active.
A large French study tracking more than 100,000 people over a decade has found that higher consumption of certain food preservatives—commonly found in processed foods and drinks—is linked to a modestly higher cancer risk. While many preservatives showed no association, several widely used ones, including potassium sorbate, sulfites, sodium nitrite, and potassium nitrate, were tied to increased risks of overall cancer and specific types such as breast and prostate cancer.
Carbohydrates don’t just fuel the body—they may also influence how the brain ages. A large long-term study found that diets high in fast-acting carbs that rapidly raise blood sugar were linked to a higher risk of dementia. People who ate more low-glycemic foods like fruit, legumes, and whole grains had a noticeably lower risk of Alzheimer’s. The quality of carbs, not just the amount, appears to matter for brain health.
Home fireplaces and wood stoves are quietly driving a large share of winter air pollution, even though only a small number of households rely on wood heat. Researchers found that wood smoke accounts for over one-fifth of Americans’ winter exposure to dangerous fine particles linked to heart disease and early death. Much of this pollution drifts into cities, where it disproportionately harms people of color. Reducing wood burning could deliver major public health benefits.
Alzheimer’s may destroy memory by flipping a single molecular switch that tells neurons to prune their own connections. Researchers found that both amyloid beta and inflammation converge on the same receptor, triggering synapse loss. Surprisingly, neurons aren’t passive victims—they actively respond to these signals. Targeting this receptor could offer a new way to protect memory beyond current amyloid-focused drugs.
A newly uncovered immune chain reaction in the gut may explain why people with inflammatory bowel disease face a much higher risk of colorectal cancer. Researchers found that a powerful inflammatory signal flips on specialized gut immune cells, which then call in waves of white blood cells from the bone marrow and rewire them in ways that help tumors grow. This process appears to damage DNA in the gut lining and create a tumor-friendly environment.
A massive new study comparing more than 100,000 people with today’s most advanced AI systems delivers a surprising result: generative AI can now beat the average human on certain creativity tests. Models like GPT-4 showed strong performance on tasks designed to measure original thinking and idea generation, sometimes outperforming typical human responses. But there’s a clear ceiling. The most creative humans — especially the top 10% — still leave AI well behind, particularly on richer creative work like poetry and storytelling.
Chronic inflammation may be quietly reshaping the colon and making it more vulnerable to early-onset colorectal cancer. Scientists found that colon tissue in younger patients was stiffer, even in areas that appeared healthy, suggesting these changes may happen before cancer develops. Lab experiments showed that cancer cells grow faster in rigid environments.
People with spinal cord injuries often lose movement even though their brains still send the right signals. Researchers tested whether EEG brain scans could capture those signals and reroute them to spinal stimulators. The system can detect when a patient is trying to move, though finer control remains a challenge. Scientists hope future improvements could turn intention into action.
A large, decades-long study suggests that signs of ADHD in childhood may have consequences that extend well beyond school and behavior. Researchers followed nearly 11,000 people from childhood into midlife and found that those with strong ADHD traits at age 10 were more likely to experience multiple physical health problems and health-related disability by their mid-40s.
Type 2 diabetes becomes more dangerous to the heart the longer a person has it. Researchers found that after several years, red blood cells can begin interfering with healthy blood vessel function. This harmful shift was not present in newly diagnosed patients but emerged over time. A small molecule inside blood cells may help flag rising cardiovascular risk early.
A new study reveals that super agers over 80 have a distinct genetic edge. They are much less likely to carry the gene most associated with Alzheimer’s risk, even when compared with other healthy seniors. Researchers also found higher levels of a protective gene variant in this group. Together, the findings help explain why some people age with remarkably youthful minds.
